X0306 4 2018-04-03 0 0001488613 Foundation Medicine, Inc. FMI 0001585017 Ryan Jason 150 SECOND STREET C/O FOUNDATION MEDICINE, INC. CAMBRIDGE MA 02141 0 1 0 0 Chief Financial Officer Common Stock 2018-04-03 4 S 0 1 72.40 D 56022 D Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units on April 1, 2018. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The reporting person previously reported restricted stock units granted to the reporting person on April 1, 2016 in Table I of the Form 4 filed on April 6, 2016. As such, no adjustment to the reporting person's beneficial interest needs to be made to reflect the vesting event related to this securities sale. /s/ Robert W. Hesslein, as Attorney-in-Fact for Jason Ryan 2018-04-05