X0306 4 2018-02-15 0 0001488613 Foundation Medicine, Inc. FMI 0001585017 Ryan Jason 150 SECOND STREET C/O FOUNDATION MEDICINE, INC. CAMBRIDGE MA 02141 0 1 0 0 Chief Financial Officer Common Stock 2018-02-15 4 M 0 15000 29.63 A 64230 D Common Stock 2018-02-15 4 S 0 15000 67.53 D 49230 D Common Stock (right to buy) 29.63 2018-02-15 4 M 0 15000 0.00 D 2024-02-06 Common Stock 15000 7147 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 7, 2017. The price reported in this Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $66.55 to $68.85, inclusive. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the ranges set forth in this footnote. This option was granted on February 6, 2014 and vested in equal quarterly installments beginning on April 1, 2014 until fully vested on January 1, 2018. /s/ Robert W. Hesslein, as Attorney-in-Fact for Jason Ryan 2018-02-20