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Note 10 - Net Loss Per Share (Tables)
3 Months Ended
Mar. 31, 2021
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Months Ended March 31,
 
   
2021
   
2020
 
Numerator
     
 
     
 
Net loss attributable to common shareholders
  $
(3,538,069
)   $
(2,947,420
)
Denominator
     
 
     
 
Weighted average common shares outstanding used to compute net loss per share, basic and diluted
   
92,587,168
     
9,130,984
 
Net loss per share of common stock, basic and diluted:
  $
(0.04
)   $
(0.32
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Three Months Ended March 31,
 
   
2021
   
2020
 
Options to purchase common stock
   
7,067,436
     
4,308,383
 
Series B convertible preferred stock
   
177,373
     
190,617
 
Warrants to purchase common stock
   
25,076,714
     
1,070,028
 
     
32,321,523
     
5,569,028