Note 14 - Stock Based Compensation - Stock-based Compensation Expense (Details) - USD ($)		3 Months Ended	12 Months Ended
	Jan. 13, 2019	Mar. 31, 2019	Dec. 31, 2020	Dec. 31, 2019
Stock compensation expense			$ 3,019,409	$ 7,102,118
General and Administrative Expense [Member]
Stock compensation expense			2,120,807	4,656,964
Research and Development Expense [Member]
Stock compensation expense			$ 898,602	2,445,154
Liability Options [Member]
Stock compensation expense	$ 1,741,919	$ 1,741,919		1,741,919
Liability Options [Member] | General and Administrative Expense [Member]
Stock compensation expense				1,074,183
Liability Options [Member] | Research and Development Expense [Member]
Stock compensation expense				$ 667,736