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Note 9 - Net Loss Per Share (Tables)
9 Months Ended
Sep. 30, 2020
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Months Ended September 30,
   
Nine Months Ended September 30,
 
   
2020
   
2019
   
2020
   
2019
 
Numerator
     
 
     
 
     
 
     
 
Net loss attributable to common shareholders
  $
(3,491,071
)   $
(3,285,914
)   $
(10,344,633
)   $
(14,621,750
)
Denominator
     
 
     
 
     
 
     
 
Weighted average common shares outstanding used to compute net loss per share, basic and diluted
   
10,162,770
     
9,130,057
     
9,496,222
     
8,283,302
 
Net loss per share of common stock, basic and diluted:
  $
(0.34
)   $
(0.36
)   $
(1.09
)   $
(1.77
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Three Months Ended September 30,
   
Nine Months Ended September 30,
 
   
2020
   
2019
   
2020
   
2019
 
Options to purchase common stock
   
7,158,387
     
4,348,383
     
5,825,082
     
2,572,413
 
Series B convertible preferred stock
   
177,562
     
191,543
     
183,544
     
281,015
 
Warrants to purchase common stock
   
1,070,028
     
1,070,028
     
1,070,028
     
1,828,085
 
     
8,405,977
     
5,609,954
     
7,078,654
     
4,681,513