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Note 10 - Net Loss Per Share (Tables)
12 Months Ended
Dec. 31, 2019
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Year Ended December 31,
 
   
2019
   
2018
 
Numerator
     
 
     
 
Net loss
  $
(17,239,777
)   $
(11,404,934
)
Deemed dividend attributable to preferred stock
   
-
     
(11,479,308
)
Net loss attributable to common shareholders
  $
(17,239,777
)   $
(22,884,242
)
Denominator
     
 
     
 
Weighted average common shares outstanding used to compute net loss per share, basic and diluted
   
8,496,964
     
4,157,746
 
Net loss per share of common stock, basic and diluted:
  $
(2.03
)   $
(5.50
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Year Ended December 31,
 
   
2019
   
2018
 
Options to purchase common stock
   
3,013,370
     
487,941
 
Series B convertible preferred stock
   
258,230
     
774,983
 
Warrants to purchase common stock
   
1,637,013
     
3,054,481
 
     
4,908,613
     
4,317,405