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Note 8 - Net Loss Per Share (Tables)
 6 Months Ended
Jun. 30, 2019
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Months Ended June 30,
    
Six Months Ended June 30,
  
   
2019
   
2018 (as restated)
   
2019
   
2018 (as restated)
 
Numerator
  
 
 
 
  
 
 
 
  
 
 
 
  
 
 
 
Net loss   $
(7,262,529
 )   $
(4,142,577
 )   $
(11,335,836
 )   $
(6,016,959
 )
Deemed dividend attributable to preferred stock
    
-
      
(11,479,308
 )    
-
      
(11,479,308
 )
Net loss attributable to common shareholders
   $
(7,262,529
 )   $
(15,621,885
 )   $
(11,335,836
 )   $
(17,496,267
 )
Denominator
  
 
 
 
  
 
 
 
  
 
 
 
  
 
 
 
Weighted average common shares outstanding used to compute net loss per share, basic and diluted    
9,126,153
      
3,073,803
      
7,852,907
      
2,864,033
  
Net loss per share of common stock, basic and diluted:
  $
(0.80
 )   $
(5.08
 )   $
(1.44
 )   $
(6.11
 )
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Three Months Ended June 30,
    
Six Months Ended June 30,
  
   
2019
    
2018
    
2019
    
2018
  
Options to purchase common stock
    
2,546,295
      
200,954
      
1,669,709
      
187,391
  
Series B convertible preferred stock
    
195,448
      
900,367
      
326,493
      
452,671
  
Warrants to purchase common stock
    
1,070,028
      
2,275,808
      
2,213,396
      
1,599,074
  
     
3,811,771
      
3,377,129
      
4,209,598
      
2,239,136