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Consolidated Statements of Stockholders' Equity (Parentheticals) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Sale of Common Stock in Class A Units [Member]    
Issuance of common stock, issuance costs   $ 65,816
Issuance of common stock and warrants, issuance costs $ 1,333,449 768,412
Issuance of common stock, issuance costs   $ 267,231