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Note 7 - Stockholders' Equity (Tables)
9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
   
Outstanding

Warrants to

Purchase

Shares
   
Exercise Price
 
Expiration Date
                     
2014 public offering
   
6,483
   
 
$540.00 
 
 
January 29, 2019
Placement agent fees for Company’s offerings
   
1,106
   
381.60
– 
540.00
 
November 4, 2018
2017 Warrant B private placement
   
441,670
   
 
3.78 
 
 
December 22, 2018
2018 Warrants
   
3,869,216
   
 
4.05 
 
 
May 30, 2022
     
4,318,475