X0306 4 2018-06-12 0 0001461993 MELINTA THERAPEUTICS, INC. /NEW/ MLNT 0001487607 GONZALO CECILIA C/O MELINTA THERAPEUTICS, INC. 300 GEORGE STREET, SUITE 301 NEW HAVEN CT 06511 1 0 0 0 Stock Option (right to buy) 7.45 2018-06-12 4 A 0 25000 0.00 A 2028-04-20 Common Stock 25000 25000 D Stock Option (right to buy) 7.45 2018-06-12 4 A 0 9100 0.00 A 2019-04-20 2028-04-20 Common Stock 9100 9100 D The option grant was approved by the compensation committee of the Company's board of directors on April 20, 2018, subject to stockholder approval of an amendment to the stock option plan under which the option was granted. The Company's stockholders approved the plan amendment on June 12, 2018. One-third of the shares underlying the stock option will vest and become exercisable on April 20, 2019. The remainder will vest and become exercisable in substantially equal monthly installments during the two year period commencing on April 20, 2019. /s/ Paul Estrem, by Power of Attorney 2018-06-14