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Condensed Consolidated Statement of Cash Flows (Unaudited) - USD ($)
6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Operating activities:    
Net loss $ 27,944,000 $ 31,905,000
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3,507,000 2,454,000
Net amortization/(accretion) of premiums/discounts on investments (78,000) 30,000
Amortization of deferred debt issuance costs 583,000 493,000
Stock-based compensation 5,799,000 5,602,000
Provision for bad debt 34,000 32,000
Non-cash inventory adjustments 809,000 565,000
Other non-cash adjustments (13,000) (123,000)
Changes in operating assets and liabilities:    
Accounts receivable 3,501,000 1,795,000
Inventories (353,000) 2,563,000
Prepaid expenses and other assets (340,000) 119,000
Accounts payable (1,853,000) (3,134,000)
Accrued compensation (853,000) (1,170,000)
Other current and non-current liabilities (622,000) (124,000)
Net cash used in operating activities (16,437,000) (28,167,000)
Investing activities:    
Purchases of property and equipment (924,000) (2,535,000)
Purchases of marketable securities (23,622,000) (10,496,000)
Proceeds from sales of marketable securities 0 13,896,000
Maturities of marketable securities 42,600,000 4,100,000
Net cash provided by investing activities 18,054,000 4,965,000
Financing activities:    
Proceeds from issuance of common stock 535,000 86,835,000
Costs incurred in conjunction with public offering 0 (5,171,000)
Principal repayment of borrowings (45,000) (964,000)
Proceeds from borrowings 0 15,000,000
Payments associated with debt issuance (20,000) (187,000)
Proceeds from stock option exercises (22,000) (170,000)
Net cash provided by (used in) financing activities 492,000 95,683,000
Effect of exchange rate changes on cash, cash equivalents, and restricted cash 28,000 (13,000)
Net increase (decrease) in cash, cash equivalents, and restricted cash 2,137,000 72,468,000
Cash, cash equivalents, and restricted cash at beginning of year 27,512,000 16,717,000
Cash, cash equivalents, and restricted cash at end of period 29,649,000 89,185,000
Non-cash investing and financing activities:    
Transfer of systems to property and equipment from inventory 956,000 (1,534,000)
Property and equipment included in accounts payable 168,000 713,000
Intellectual property acquisitions included in other current liabilities 0 500,000
Supplemental cash flow information:    
Cash paid for income taxes, net 113,000 54,000
Cash paid for interest $ 1,003,000 $ 574,000