<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001486672</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000879407</issuerCik>
      <issuerName>ARROWHEAD PHARMACEUTICALS, INC.</issuerName>
      <secFileNumber>001-38042</secFileNumber>
      <issuerAddress>
        <com:street1>177 E COLORADO BLVD</com:street1>
        <com:street2>SUITE 700</com:street2>
        <com:city>PASADENA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>91105</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>626-696-4702</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Myszkowski Kenneth Allen</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch </name>
        <address>
          <com:street1>75 Rockefeller Plz</com:street1>
          <com:street2>2nd Flr</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10019</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10000</noOfUnitsSold>
      <aggregateMarketValue>196877.46</aggregateMarketValue>
      <noOfUnitsOutstanding>124434442</noOfUnitsOutstanding>
      <approxSaleDate>01/07/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/04/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Ken Myszkowski</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
      <paymentDate>01/07/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ken Myszkowski</name>
        <address>
          <com:street1>177 E Colorado Blvd</com:street1>
          <com:street2>Ste. 700</com:street2>
          <com:city>Pasadena</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91105</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/06/2025</saleDate>
      <amountOfSecuritiesSold>27167</amountOfSecuritiesSold>
      <grossProceeds>538565.20</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>01/07/2025</noticeDate>
      <signature>Ken Myszkowski</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
