Liquidity, Going Concern and Management Plans - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cash, cash equivalents, restricted cash, and restricted cash equivalents	$ 364,806		$ 343,226
Working capital deficit	65,000
Accumulated deficit	(1,641,701)		$ (1,558,088)
Net loss from continuing operations	(83,368)	$ (128,363)
ATM Offering
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sale of stock, consideration received on transaction	106,100
Payments of stock issuance costs	$ 2,500
Number of shares issued in transaction	71,444,729
Sale of stock, price per share (in usd per share)	$ 1.52