Liquidity, Going Concern and Management Plans - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Jun. 27, 2022	Jan. 01, 2022	Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cash, cash equivalents, restricted cash, and restricted cash equivalents	$ 278,809		$ 278,809				$ 379,406
Short-term investments	100,000		100,000		$ 100,000		0
Working capital deficit	126,700		126,700
Accumulated deficit	1,253,459		1,253,459			$ 996,611	$ 1,009,293
Net loss	116,274	$ 94,930	$ 257,091	$ 165,116
Sales agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Proceeds from issuance of common stock	220,200
Payments of stock issuance costs	$ 4,500
Number of shares issued in transaction	29,843,580
Sale of stock, price per share (in usd per share)	$ 7.53		$ 7.53