X0306 4 2022-03-01 0 0001484612 Outset Medical, Inc. OM 0001304125 Trigg Leslie 3052 ORCHARD DRIVE SAN JOSE CA 95134 1 1 0 0 Chair and CEO Common Stock 2022-03-01 4 M 0 20000 3.88 A 331613 D Common Stock 2022-03-01 4 S 0 20000 43.4873 D 311613 D Common Stock 8770 I Trigg Family Trust Non-Qualified Stock Option (right to buy) 3.88 2022-03-01 4 M 0 20000 0.0 D 2027-09-19 Common Stock 20000 75711 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2020. The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from: $42.00-$42.99 - 3,394 shares; $43.00-$43.99 - 12,474 shares; $44.00 - $44.99 - 4,132 shares. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Includes 500 shares of Common Stock acquired pursuant to the Outset Medical, Inc. 2020 Employee Stock Purchase Plan ("ESPP"), for the purchase period of September 1, 2021 to February 28, 2022. This transaction is exempt from Rule 16b-3(c). This option vested in 48 equal monthly installments beginning on October 19, 2017. By: John L Brottem For: Leslie Trigg 2022-03-02