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    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
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        <entityName>Outset Medical, Inc.</entityName>
        <issuerAddress>
            <street1>1830 BERING DRIVE</street1>
            <city>SAN JOSE</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>95112</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>669-231-8200</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>Home Dialysis Plus, Ltd.</previousName>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

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            <relatedPersonName>
                <firstName>Scott</firstName>
                <lastName>Bartos</lastName>
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                <street1>c/o Outset Medical, Inc.</street1>
                <street2>1830 Bering Drive</street2>
                <city>San Jose</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95112</zipCode>
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                <lastName>Chou</lastName>
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                <street2>1830 Bering Drive</street2>
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                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>95112</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>D. Keith</firstName>
                <lastName>Grossman</lastName>
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                <street1>c/o Outset Medical, Inc.</street1>
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                <firstName>In Seon</firstName>
                <lastName>Hwang</lastName>
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                <street2>1830 Bering Drive</street2>
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                <zipCode>95112</zipCode>
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                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
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                <firstName>Annette</firstName>
                <lastName>Rodriguez</lastName>
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                <zipCode>95112</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Leslie</firstName>
                <lastName>Trigg</lastName>
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            <relatedPersonAddress>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeff</firstName>
                <lastName>Mack</lastName>
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            <relatedPersonAddress>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2017-04-19</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>1</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>76483991</totalOfferingAmount>
            <totalAmountSold>76483991</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>27</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Outset Medical, Inc.</issuerName>
                <signatureName>/s/ Leslie Trigg</signatureName>
                <nameOfSigner>Leslie Trigg</nameOfSigner>
                <signatureTitle>President and Chief Executive Officer</signatureTitle>
                <signatureDate>2017-05-02</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
