X0306 4 2021-04-01 0001484612 Outset Medical, Inc. OM 0001304125 Trigg Leslie 3052 ORCHARD DRIVE SAN JOSE CA 95134 true true President & CEO Common Stock 2021-04-01 4 M 0 23766 1.11 A 274424 D Common Stock 2021-04-01 4 M 0 19037 1.11 A 293461 D Common Stock 2021-04-01 4 M 0 14697 1.11 A 308158 D Common Stock 2021-04-01 4 S 0 27538 55.0046 D 280620 D Common Stock 2021-04-01 4 S 0 29962 55.7433 D 250658 D Common Stock 8770 I Held by Trigg Family Trust U/A DTD 01/01/2002 Stock Option (Right to Buy) 1.11 2021-04-01 4 M 0 23766 0 D 2023-09-24 Common Stock 23766 0 D Stock Option (Right to Buy) 1.11 2021-04-01 4 M 0 19037 0 D 2024-09-05 Common Stock 19037 0 D Stock Option (Right to Buy) 1.11 2021-04-01 4 M 0 14697 0 D 2025-03-13 Common Stock 14697 53081 D These shares of common stock of the Issuer ("Shares") are held directly by The Trigg Family Trust U/A DTD 01/01/2002, for which the reporting person and her spouse serve as trustees. This option vested in 48 equal monthly installments beginning on May 1, 2012. This option vested in 48 equal monthly installments beginning on October 5, 2014. This option vested in 48 equal monthly installments beginning on December 17, 2014. The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from $54.23 to $55.20, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (5). The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from $55.28 to $56.235, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (6). The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2020. /s/ John L. Brottem, attorney-in-fact for Leslie Trigg 2021-04-05