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March 25, 2021

Via EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549-3720

        Re: Outset Medical, Inc. Draft Registration Statement on Form S-1

Ladies and Gentlemen:

On behalf of Outset Medical, Inc. (the “Company”), we hereby confidentially submit a draft Registration Statement on Form S-1 (the “Registration Statement”) pursuant to Section 6(e) of the Securities Act of 1933, as amended (the “Securities Act”), for non-public review by the Staff of the Securities and Exchange Commission prior to the public filing of the Registration Statement. The Registration Statement relates to the public offering by the Company, and by certain stockholders, of shares of the Company’s common stock. The Company qualifies as an “emerging growth company” within the meaning of Section 6(e) of the Securities Act. The Company will publicly file its Registration Statement and nonpublic draft submission such that it is publicly available on the EDGAR system at least 48 hours prior to any requested effective time and date.

Please do not hesitate to contact me at (212) 839-5931 with any questions you may have regarding this confidential submission.

Very truly yours,

/s/ Robert A. Ryan

Robert A. Ryan

cc:	Leslie Trigg, President, Chief Executive Officer and Director
	John L. Brottem, General Counsel
	Rebecca Chambers, Chief Financial Officer
	Frank F. Rahmani, Sidley Austin LLP
	Helen Theung, Sidley Austin LLP
	Nathan Ajiashvili, Latham & Watkins LLP
	Brian Cuneo, Latham & Watkins LLP
	Salvatore Vanchieri Jr., Latham & Watkins LLP

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