SIDLEY AUSTIN LLP 787 SEVENTH AVENUE NEW YORK, NY 10019 +1 212 839 5300 +1 212 839 5599 FAX   AMERICA • ASIA PACIFIC • EUROPE RRYAN@SIDLEY.COM +1 212 839 5931

November 18, 2020

Via EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549-3720

Re: Outset Medical, Inc.

Draft Registration Statement on Form S-1

Ladies and Gentlemen:

On behalf of Outset Medical, Inc. (the “Company”), we hereby confidentially submit a draft Registration Statement on Form S-1 (the “Registration Statement”) pursuant to Section 6(e) of the Securities Act of 1933, as amended (the “Securities Act”), for non-public review by the Staff of the Securities and Exchange Commission prior to the public filing of the Registration Statement. The Registration Statement relates to the public offering by certain stockholders of shares of the Company’s common stock. The Company qualifies as an “emerging growth company” within the meaning of Section 6(e) of the Securities Act. The Company will publicly file its Registration Statement and nonpublic draft submission such that it is publicly available on the EDGAR system in accordance with SEC regulations prior to any requested effective time and date.

Please do not hesitate to contact me at (212) 839-5931 with any questions you may have regarding this confidential submission.

Very truly yours,

/s/ Robert A. Ryan

Robert A. Ryan

cc: Leslie Trigg, President, Chief Executive Officer and Director

John L. Brottem, General Counsel

Rebecca Chambers, Chief Financial Officer

Frank F. Rahmani, Sidley Austin LLP

Helen Theung, Sidley Austin LLP

Nathan Ajiashvili, Latham & Watkins LLP

Brian Cuneo, Latham & Watkins LLP

Sidley Austin (NY) LLP is a Delaware limited liability partnership doing business as Sidley Austin LLP and practicing in affiliation with other Sidley Austin partnerships.