X0306 4 2021-05-03 0001484612 Outset Medical, Inc. OM 0001218702 GROSSMAN D KEITH 3052 ORCHARD DRIVE SAN JOSE CA 95134 true Common Stock 2021-05-03 4 M 0 2592 1.11 A 2592 D Common Stock 2021-05-03 4 S 0 2274 57.873 D 318 D Common Stock 2021-05-03 4 S 0 100 58.5 D 218 D Common Stock 2021-05-03 4 S 0 218 59.789 D 0 D Common Stock 11604 I Held by The D. Keith and Hallie H. Grossman Family Living Trust Stock Option (Right to Buy) 1.11 2021-05-03 4 M 0 2592 0 D 2024-06-16 Common Stock 2592 79733 D These shares of common stock of the Issuer ("Shares") are held directly by The D. Keith and Hallie H. Grossman Family Living Trust, for which the reporting person and his spouse serve as trustees. This option vested 25% on April 15, 2015, and then in 36 equal monthly installments thereafter. The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from $57.46 to $58.45, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (3). The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from $59.77 to $60.00, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (4). The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2020. /s/ John L. Brottem, attorney-in-fact for Donald Keith Grossman 2021-05-05