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                             March 30, 2021

       Rebecca Chambers
       Chief Financial Officer
       Outset Medical, Inc.
       3052 Orchard Dr.
       San Jose, California 95134

                                                        Re: Outset Medical,
Inc.
                                                            Draft Registration
Statement on Form S-1
                                                            Submitted March 25,
2021
                                                            CIK No. 0001484612

       Dear Ms. Chambers:

                                                        This is to advise you
that we do not intend to review your registration statement.

               We request that you publicly file your registration statement no
later than 48 hours prior
       to the requested effective date and time. Please refer to Rules 460 and
461 regarding requests for
       acceleration. We remind you that the company and its management are
responsible for the
       accuracy and adequacy of their disclosures, notwithstanding any review,
comments, action or
       absence of action by the staff.

                                                        Please contact Tim
Buchmiller at (202) 551-3635 with any questions.




                             Sincerely,


                             Division of Corporation Finance

                             Office of Life Sciences
       cc:                                              Robert A. Ryan, Esq.