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                            September 3, 2020

       Leslie Trigg
       President and Chief Executive Officer
       Outset Medical, Inc.
       3952 Orchard Drive
       San Jose, CA 95134

                                                        Re: Outset Medical,
Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed August 21,
2020
                                                            File No. 333-248225

       Dear Ms. Trigg:

                                                        We have reviewed your
registration statement and have the following comment.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comment applies to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this comment, we may have additional comments.

       Registration Statement on Form S-1 filed August 21, 2020

       15. Subsequent Events, page F-62

   1.                                                   Please disclose the
specific date through which subsequent events were evaluated in
                                                        accordance with ASC
855-10-50-1.
               We remind you that the company and its management are
responsible for the accuracy
       and adequacy of their disclosures, notwithstanding any review, comments,
action or absence of
       action by the staff.

              Refer to Rules 460 and 461 regarding requests for acceleration.
Please allow adequate
       time for us to review any amendment prior to the requested effective
date of the registration
       statement.
 Leslie Trigg
Outset Medical, Inc.
September 3, 2020
Page 2

       You may contact Tracey Houser at 202-551-3736 or Sasha Parikh at
202-551-3627 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Jeffrey Gabor at 202-551-2544 or Suzanne Hayes at 202-551-3675 with any
other
questions.



                                                        Sincerely,
FirstName LastNameLeslie Trigg
                                                        Division of Corporation
Finance
Comapany NameOutset Medical, Inc.
                                                        Office of Life Sciences
September 3, 2020 Page 2
cc:       Robert A. Ryan, Esq.
FirstName LastName