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            <officerTitle>SEE REMARKS</officerTitle>
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    <footnotes>
        <footnote id="F1">Certain of these shares are represented by previously reported restricted stock units (&quot;RSUs&quot;). Pursuant to the Agreement and Plan of Merger, dated as of April 5, 2026, by and among Soleno Therapeutics, Inc. (the &quot;Company&quot;), Neocrine Biosciences, Inc. (&quot;Parent&quot;) and Sigma Merger Sub, Inc. (&quot;Merger Sub&quot;), on May 18, 2026, Merger Sub merged with and into the Company (the &quot;Merger&quot;), with the Company continuing as the surviving corporation and a wholly owned subsidiary of Parent. In connection with the Merger, each issued and outstanding vested and unvested RSU was cancelled and converted into the right to receive an amount equal to $53.00 in cash (the &quot;Merger Consideration&quot;).</footnote>
        <footnote id="F2">In connection with the Merger, each issued and outstanding share of the Company's Common Stock was cancelled and converted into the right to receive an amount in cash equal to the Merger Consideration.</footnote>
        <footnote id="F3">At the effective time of the Merger, this option was cancelled in exchange for a cash payment equal to (x) the difference between the Merger Consideration and the per share exercise price of the option, multiplied by (y) the number of shares covered by the option as of immediately prior to such cancellation.</footnote>
    </footnotes>

    <remarks>Officer title: SVP Global Clinical Operations and Patient Advocacy</remarks>

    <ownerSignature>
        <signatureName>/s/ Anish Bhatnagar, Attorney-in-Fact</signatureName>
        <signatureDate>2026-05-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
