Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax

The geographical distribution of income (loss) before income taxes are summarized below:

	December 31,
	2016			2015
United States	$	(11,807,891	)	$	(11,908,546	)
Foreign	(235,623		)	—
Total	$	(12,043,514	)	$	(11,908,546	)

Reconciliation of Income Tax Expense by Applying Statutory U.S. Federal Income Tax Rate to Income Before Income Taxes

A reconciliation of income tax expense with amounts determined by applying the statutory U.S. federal income tax rate to income before income taxes is as follows:

	December 31,
	2016			2015
Tax on the loss before income tax expense computed at the federal statutory rate of 34%	$	(4,094,922	)	$	(5,408,551	)
State tax (benefit) at statutory rate, net of federal benefit	(266,258		)	(928,107		)
Foreign Rate Differential	35,343			—
Change in Valuation Allowance	4,260,571			4,199,154
Change in research and development credits	(129,974		)	(60,991		)
Stock Based Compensation - ISO	323,537			—
Change in fair value of warrants	(619,067		)	1,493,215
Change in state tax rate	345,172			—
Other	167,298			705,280
Provision for deferred taxes	$	21,700		$	—
Effective income tax rate	—		%	—		%

Significant Components of Company's Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred tax assets and liabilities are as follows at December 31, 2016 and 2015:

	December 31,
	2016			2015
Non-Current Deferred Tax Assets:
Reserves and accruals	$	212,479		$	287,850
Net Operating Loss Carryforwards	30,291,080			26,174,912
Research and development credits	1,580,253			1,381,296
Intangible Assets	(68,894		)	(74,113		)
Fixed Assets	2,978			9,080
Total Non-Current Deferred Tax Assets	32,017,896			27,779,025
Valuation Allowance	(32,039,596		)	(27,779,025		)
Net Deferred Tax Liability	$	(21,700	)	$	—

Summary of Gross Unrecognized Tax Benefits

The following tables summarize the activities of gross unrecognized tax benefits:

	December 31,
	2016		2015
Beginning balance	691,697		673,247
Increase related to prior year tax positions	—		—
Decreases related to prior year tax positions	35,804		(13,207		)
Increase related to current year tax positions	67,461		31,657
Decreases related to current year tax positions	—		—
Ending Balance	$	794,962	$	691,697