SCHEDULE 13G/A 0001930214 XXXXXXXX LIVE 3 Common Stock, $0.001 par value per share 09/30/2025 0001484565 Soleno Therapeutics, Inc. 834203309 100 Marine Parkway Suite 400 Redwood City CA 94065 Rule 13d-1(c) Vivo Opportunity Fund Holdings, L.P. b DE 2251160.00 0.00 2251160.00 0.00 2251160.00 N 4.2 PN The shares of common stock, $0.001 par value (the "Common Stock") of Soleno Therapeutics, Inc. (the "Issuer") are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. The percent of class was calculated based upon 53,710,025 shares of Common Stock of the Issuer outstanding as of October 31, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission ("SEC") on November 4, 2025. Vivo Opportunity, LLC b DE 2251160.00 0.00 2251160.00 0.00 2251160.00 N 4.2 OO The shares of Common Stock of the Issuer are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. The percent of class was calculated based upon 53,710,025 shares of Common Stock of the Issuer outstanding as of October 31, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 4, 2025. Vivo Opportunity Cayman Fund, L.P. b E9 27043.00 0.00 27043.00 0.00 27043.00 N 0.1 PN The shares of Common Stock of the Issuer are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. The percent of class was calculated based upon 53,710,025 shares of Common Stock of the Issuer outstanding as of October 31, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 4, 2025. Vivo Opportunity Cayman, LLC b E9 27043.00 0.00 27043.00 0.00 27043.00 N 0.1 OO The shares of Common Stock of the Issuer are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. The percent of class was calculated based upon 53,710,025 shares of Common Stock of the Issuer outstanding as of October 31, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 4, 2025. Soleno Therapeutics, Inc. 100 Marine Parkway, Suite 400, Redwood City, CA 94065 Vivo Opportunity Fund Holdings, L.P. and its General Partner Vivo Opportunity, LLC Vivo Opportunity Cayman Fund, L.P. and its General Partner Vivo Opportunity Cayman, LLC 192 Lytton Avenue, Palo Alto, CA 94301. Vivo Opportunity Fund Holdings, L.P., a Delaware limited partnership. Vivo Opportunity, LLC, a Delaware limited liability company. Vivo Opportunity Cayman Fund, L.P., a Cayman Islands limited partnership. Vivo Opportunity Cayman, LLC, a Cayman Islands limited liability company. Y The information set forth in rows 5 through 11 of the cover pages is incorporated by reference into this Item 4. The information set forth in rows 5 through 11 of the cover pages is incorporated by reference into this Item 4. Vivo Opportunity Fund Holdings, L.P. 2,251,160 Vivo Opportunity, LLC 2,251,160 Vivo Opportunity Cayman Fund, L.P. 27,043 Vivo Opportunity Cayman, LLC. 27,043 Vivo Opportunity Fund Holdings, L.P. 0 Vivo Opportunity, LLC 0 Vivo Opportunity Cayman Fund, L.P. 0 Vivo Opportunity Cayman, LLC. 0 Vivo Opportunity Fund Holdings, L.P. 2,251,160 Vivo Opportunity, LLC 2,251,160 Vivo Opportunity Cayman Fund, L.P. 27,043 Vivo Opportunity Cayman, LLC. 27,043 Vivo Opportunity Fund Holdings, L.P. 0 Vivo Opportunity, LLC 0 Vivo Opportunity Cayman Fund, L.P. 0 Vivo Opportunity Cayman, LLC. 0 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Vivo Opportunity Fund Holdings, L.P. /s/ Kevin Dai 11/14/2025 Vivo Opportunity, LLC /s/ Kevin Dai 11/14/2025 Vivo Opportunity Cayman Fund, L.P. /s/ Kevin Dai 11/14/2025 Vivo Opportunity Cayman, LLC /s/ Kevin Dai 11/14/2025