X0508 4 2023-12-11 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001422484 Mackaness James H 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 0 1 0 0 Chief Financial Officer 0 Common Stock 2023-12-11 4 M 0 15000 2.595 A 44610 D Common Stock 2023-12-11 4 S 0 6252 35.4872 D 38358 D Common Stock 2023-12-11 4 S 0 12381 36.1567 D 25977 D Common Stock 2023-12-11 4 S 0 13849 37.0645 D 12128 D Employee stock option (right to buy) 2.595 2023-12-11 4 M 0 15000 0.00 D 2032-07-27 Common Stock 15000 5000 D The 1-for-15 reverse stock split of the Issuer's Common Stock, effected August 26, 2022, was reflected in a Form 4 filed by the Reporting Person on October 14, 2023. The number of shares reported as beneficially owned following the reported transaction has been reduced by two shares to reflect share rounding as a result of such stock split. This transaction was executed in multiple trades at prices ranging from $34.83 to $35.82. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $35.83 to $36.76. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $36.84 to $37.26. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. The option, originally for 20,000 shares, vested as to one fourth of the shares on August 1, 2022 and each three-month anniversary thereafter, subject to the Reporting Person continuing to be a Service Provider through each such date. /s/ James Mackaness 2023-12-13