X0508 4 2023-11-30 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001180469 MARIO ERNEST 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94062 1 0 0 0 0 Common Stock 2023-11-30 4 G 0 8700 0.00 D 128089 D Common Stock 20752 I See footnote Common Stock 0 I See footnote Common Stock 0 I See footnote The number of shares held directly no longer includes 20,752 shares which are now reported below as held by Mildred Mario Nonexempt Trust, of which the Reporting Person is a co-trustee. The number of shares beneficially owned has been reduced by one share pursuant to an internal review of the Reporting Person's holdings. The shares are held by Mildred Mario Nonexempt Trust, of which the Reporting Person is a co-trustee. The Reporting Person is no longer reporting indirect beneficial ownership of shares held by the by the Mario 1998 Irrevocable Trust, as the Reporting Person does not have beneficial ownership of such shares. The Reporting Person is no longer reporting indirect beneficial ownership of shares held by the by the Martha Mario Nonelective Trust, as the Reporting Person does not have beneficial ownership of such shares. /s/ Anish Bhatnagar, Attorney-in-Fact 2023-12-04