X0508 4 2023-11-30 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001422484 Mackaness James H 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 0 1 0 0 Chief Financial Officer 0 Common Stock 2023-11-30 4 S 0 4186 28.6519 D 21303 D These shares were sold to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). This transaction was executed in multiple trades at prices ranging from $28.38 to $29.11. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. Certain of these securities are RSUs. Each RSU represents a contingent right to receive one share of Common Stock, subject to the applicable vesting schedule and conditions of each RSU. /s/ James Mackaness 2023-12-04