X0508 4 2023-11-28 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001422484 Mackaness James H 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 0 1 0 0 Chief Financial Officer 0 Common Stock 2023-11-28 4 S 0 3205 27.0262 D 30365 D Common Stock 2023-11-28 4 S 0 673 27.5948 D 29692 D Common Stock 2023-11-29 4 S 0 2162 27.4273 D 27530 D Common Stock 2023-11-29 4 S 0 2041 28.2649 D 25489 D These shares were sold to cover tax withholding obligations in connection with the vesting of restricted stock units. This transaction was executed in multiple trades at prices ranging from $26.465 to $27.46. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $27.465 to $28.34. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $26.89 to $27.885. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $27.89 to $28.57. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. /s/ James Mackaness 2023-11-30