X0306 4 2022-08-26 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001180469 MARIO ERNEST 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94062 1 0 0 0 Common Stock 157542 D Common Stock 62000 I See footnote Common Stock 20752 I See footnote Stock option (right to buy) 535.50 2024-08-04 Common Stock 663 663 D Stock option (right to buy) 535.50 2024-08-04 Common Stock 93 93 D Stock option (right to buy) 135.00 2025-01-11 Common Stock 66 66 D Stock option (right to buy) 349.50 2025-05-15 Common Stock 66 66 D Stock option (right to buy) 90.00 2026-06-08 Common Stock 361 361 D Stock option (right to buy) 54.00 2027-05-08 Common Stock 601 601 D Stock option (right to buy) 30.60 2028-06-11 Common Stock 1062 1062 D Stock option (right to buy) 39.45 2029-06-10 Common Stock 823 823 D Stock option (right to buy) 51.15 2030-05-18 Common Stock 635 635 D Stock option (right to buy) 33.60 2031-01-08 Common Stock 2666 2666 D Stock option (right to buy) 15.30 2031-06-01 Common Stock 2124 2124 D Stock option (right to buy) 2.55 2032-06-01 Common Stock 2666 2666 D Warrant (right to buy) 4.50 2022-03-31 2027-03-31 Common Stock 62000 62000 D Warrant (right to buy) 4.50 2022-03-31 2027-03-31 Common Stock 62000 62000 I See footnote The number of shares beneficially owned reflects the 1-for-15 reverse stock split effected August 26, 2022. The securities are held by Mario 1998 Irrevocable Trust, of which the Reporting Person is the ultimate beneficiary. The shares are held by Martha Mario Nonelective Trust. The per share exercise price and number of shares subject to the option reflect the 1-for-5 reverse stock split effected October 15, 2017 and the 1-for-15 reverse stock split effected August 26, 2022. All of the shares subject to this option are fully vested and exercisable as of the date hereof. The per share exercise price and number of shares subject to the option reflect the 1-for-15 reverse stock split effected August 26, 2022. The shares subject to the Option shall vest on the earlier of the twelve-month anniversary of June 1, 2022 or the day before the next annual stockholder meeting, subject to Reporting Person continuing to be a Service Provider through each such date. The per share exercise price and number of shares subject to the warrant reflect the 1-for-15 reverse stock split effected August 26, 2022. /s/ Anish Bhatnagar, Attorney-in-Fact 2022-10-14