X0306 4 2022-08-26 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001422484 Mackaness James H 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 0 1 0 0 Chief Financial Officer Common Stock 4486 D Employee stock option (right to buy) 30.75 2030-11-16 Common Stock 20000 20000 D Employee stock option (right to buy) 5.10 2032-01-28 Common Stock 13000 13000 D Employee stock option (right to buy) 2.595 2032-07-27 Common Stock 20000 20000 D Warrant (right to buy) 4.50 2022-03-31 2027-03-31 Common Stock 2666 2666 D The number of shares beneficially owned reflects the 1-for-15 reverse stock split effected August 26, 2022. The per share exercise price and number of shares subject to the option reflect the 1-for-15 reverse stock split effected August 26, 2022. Twenty-five percent (25%) of the shares subject to the Option shall vest on the one year anniversary of November 11, 2020 (the "Vesting Commencement Date"), and one forty-eighth (1/48) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date (which is November 11, 2020), such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person continuing to be a Service Provider through each such date. Following the initial twelve month term, if the Reporting Person is terminated without cause or his employment is voluntarily terminated for good reason within the period three month prior to through six months following a change of control then he will receive: 100% acceleration of shares subject to the option. One forty-eighth (1/48th) of the shares subject to the Option shall vest on the first month anniversary of January 1, 2022 (the "Vesting Commencement Date"), and one forty-eighth (1/48th) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date (and if there is no corresponding day, on the last day of the month), such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person continuing to be a Service Provider through each such date. One fourth of the shares subject to the option shall vest on August 1, 2022 and each three-month anniversary thereafter, subject to the Reporting Person continuing to be a Service Provider through each such date. The per share exercise price and number of shares subject to the warrant reflect the 1-for-15 reverse stock split effected August 26, 2022. /s/ James Mackaness 2022-10-14