X0206 3/A 2019-01-24 2019-01-28 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001766042 Hirano Patricia C 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 0 1 0 0 See Remarks Employee stock option (right to buy) 2.95 2027-04-19 Common Stock 4000 D Employee stock option (right to buy) 1.60 2028-02-07 Common Stock 90000 D This option grant was omitted from the original Form 3 filed January 28, 2019. Twenty-five percent (25%) of the shares subject to the Option shall vest on the one year anniversary of April 19, 2017 (the "Vesting Commencement Date"), and one forty-eighth (1/48) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date, such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person continuing to be a Service Provider through each such date. The per share exercise price and number of shares subject to the Option is as of January 24, 2019. One forty-eighth (1/48) of the shares subject to the Option shall vest on the first month anniversary of February 7, 2018 (the "Vesting Commencement Date"), and one forty-eighth (1/48) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date, such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person continuing to be a Service Provider through each such date. Officer title: Vice President, Regulatory Affairs /s/ Anish Bhatnagar, Attorney-in-Fact 2022-10-14