X0306 4 2016-01-10 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001643441 Yen Kristen 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 0 1 0 0 See Remarks Employee stock option (right to buy) 120.75 2016-01-10 4 A 0 666 0.00 A 2026-01-10 Common Stock 666 666 D Employee stock option (right to buy) 44.25 2017-04-19 4 A 0 1741 0.00 A 2027-04-19 Common Stock 1741 1741 D Employee stock option (right to buy) 24.00 2018-02-07 4 A 0 5000 0.00 A 2028-02-07 Common Stock 5000 5000 D The per share exercise price and number of shares subject to the option reflect the 1-for-5 reverse stock split effected October 15, 2017 and the 1-for-15 reverse stock split effected August 26, 2022. One forty-eighth (1/48) of the shares subject to the Option shall vest on the first month anniversary of January 10, 2016 (the "Vesting Commencement Date"), and one forty-eighth (1/48) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date, such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person continuing to be a Service Provider through each such date. Twenty-five percent (25%) of the shares subject to the Option shall vest on April 19, 2017 (the "Grant Date") and one forty-eighth (1/48) of the remaining shares subject to the Option shall vest each month thereafter on the same day of the month as the Grant Date, such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Grant Date, subject to the Reporting Person continuing to be a Service Provider through each such date. The per share exercise price and number of shares subject to the option reflect the 1-for-15 reverse stock split effected August 26, 2022. One forty-eighth (1/48) of the shares subject to the Option shall vest on the first month anniversary of February 7, 2018 (the "Vesting Commencement Date"), and one forty-eighth (1/48) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date, such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person continuing to be a Service Provider through each such date. Officer title: Vice President, Clinical Operations /s/ Anish Bhatnagar, Attorney-in-Fact 2022-10-14