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Stockholders' Equity (Deficit) - Summary of Stock Option and Restricted Stock Unit Transactions (Detail) - Stock Options [Member] - $ / shares
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]      
Options granted 283,919 230,854  
2014 Plan and Inducement Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]      
Beginning balance 408,329 189,142  
Options granted 283,919 230,854  
Options canceled/forfeited (5,674) (11,667)  
Ending balance 686,574 408,329 189,142
Options exercisable at end of period (shares) 357,573    
Options vested and expected to vest at end of period (shares) 663,616    
Weighted-Average Exercise Price per Share      
Beginning balance (in dollars per share) $ 46.28 $ 62.63  
Options granted (in dollars per share) 3.56 31.95  
Options canceled/forfeited (in dollars per share) 19.31 28.65  
Ending balance (in dollars per share) 28.83 $ 46.28 $ 62.63
Options exercisable at end of period (in dollars per share) 39.54    
Options vested and expected to vest at end of period (in dollars per share) $ 28.67    
Weighted Average Remaining Contractual Term      
Options outstanding at end of period 7 years 11 months 4 days 7 years 11 months 8 days 7 years 7 months 13 days
Options exercisable at end of period 7 years 2 months 15 days    
Options vested and expected to vest at end of period 7 years 11 months 4 days