XML 56 R44.htm IDEA: XBRL DOCUMENT v3.23.1
Stockholders' Equity (Deficit) - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Dec. 16, 2022
Mar. 31, 2022
Dec. 31, 2022
Dec. 31, 2021
Aug. 26, 2022
Jul. 31, 2021
Dec. 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Convertible preferred stock, shares authorized     10,000,000 10,000,000 10,000,000    
Stock-based compensation expense     $ 2,530,000 $ 3,276,000      
Expected dividend yield     0.00% 0.00%      
Weighted average grant date fair value per option granted (in dollars per share)     $ 2.62 $ 25.5      
Number of shares available for issuance under the plan on the first day of each year     8,159,382 5,324,287      
Minimum [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Ownership interest of voting rights of all classes of stock (percent)     10.00%        
2020 Inducement Equity Incentive Plan [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Number of shares available for grant     85,668        
Stock Options [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Income tax benefits recognized from stock-based compensation     $ 0 $ 0      
Number of options granted     283,919 230,854      
Expected dividend yield     0.00%        
Future stock-based compensation for unvested employee options granted and outstanding     $ 3,200,000        
Future stock-based compensation, requisite service period     1 year 9 months 18 days        
Stock Options [Member] | 2014 Equity Incentive Plan [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Vesting period     4 years        
Number of shares available for grant     16,930        
Stock Options [Member] | 2014 Equity Incentive Plan [Member] | Minimum [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Percentage of fair market value     110.00%        
Stock Options [Member] | 2014 Equity Incentive Plan [Member] | Maximum [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Contractual term of option     10 years        
ISOs [Member] | 2014 Equity Incentive Plan [Member] | Maximum [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Contractual term of option     5 years        
Performance-Based Options [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Number of options granted       47,250      
Restricted Stock Units [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Vesting period     4 years        
Unrecognized stock based compensation expense     $ 600,000        
Stock units granted     8,965 11,863      
Vesting percentage     100.00%        
Fair value of restricted stock units vested     $ 100,000 $ 300,000      
Weighted average grant-date fair value of all restricted stock units granted     $ 5.33 $ 15.68      
Weighted average remaining vesting period     1 year 1 month 6 days        
Restricted Stock Units [Member] | 2014 Equity Incentive Plan [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Warrants expiration date     $ 57.75 $ 57.75     $ 57.75
Stock units granted     8,965 11,863      
Weighted average grant-date fair value of all restricted stock units granted     $ 5.33 $ 15.75      
Warrants to Purchase Stock [Member] | 2010 and 2012 Convertible Promissory Notes [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Warrants outstanding (in shares)     6,804        
Exercise price of warrants (in dollars per share)     $ 365.25        
Warrants term     10 years        
Warrants expiration period     2024-11        
Underwriter [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Warrants outstanding (in shares)     1,100        
Exercise price of warrants (in dollars per share)     $ 535.50        
Warrants term     10 years        
Warrants expiration period     2024-11        
Controlled Equity Offering Sales Agreement [Member] | Cantor [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Issuance of common stock (shares)     104,773        
Common stock, maximum aggregate purchase price           $ 25,000,000.0  
Net proceeds from sale of common stock     $ 300,000        
Securities Purchase Agreement [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Number of common stock purchased upon issuance of warrants 22,598,870            
Exercise price of warrants (in dollars per share) $ 0.4425            
Tranche A [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Warrants outstanding (in shares) 8,598,870            
Warrants and rights immediately exercisable term 30 days            
Warrants expire term prior to anniversary date of issuance 3 years 6 months            
Exercise price of warrants (in dollars per share) $ 1.75            
Exercisable warrants maximum aggregate exercise price $ 15,000,000.0            
Tranche B [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Warrants outstanding (in shares) 14,000,000            
Warrants expire term prior to anniversary date of issuance 3 years 6 months            
Warrants and rights exercisable term from following receipt of U.S. Food and drug administration approval 30 days            
Exercise price of warrants (in dollars per share) $ 2.50            
Exercisable warrants maximum aggregate exercise price $ 35,000,000.0            
Underwritten Public Offering [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Issuance of common stock (shares)   2,666,666          
Price per unit   $ 3.75          
Number of common stock purchased upon issuance of warrants   1,333,333          
Public offering price per pre-funded warrant   $ 3.60          
Per share exercise price for pre-funded warrant   $ 0.15          
Measurement term   5 years          
Exercise price of warrants (in dollars per share)   $ 4.50          
Proceeds from offering after deducting underwriting discount and other estimated offering expenses   $ 13,800,000          
Net proceeds from sale of common stock   $ 13,800,000 $ 60,000,000.0        
Employee Stock Purchase Plan [Member]              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]              
Number of shares available for grant     1,864        
Percentage of outstanding stock maximum     1.00%        
Number of shares available for issuance under the plan on the first day of each year     3,729        
Number of shares purchases by employees     0