Summary of Significant Accounting Policies - Additional Information (Detail) $ / shares in Units, $ in Millions			12 Months Ended
	Aug. 26, 2022 $ / shares shares	Jun. 01, 2022	Dec. 31, 2022 USD ($) Segment $ / shares shares	Dec. 31, 2021 $ / shares shares
Schedule Of Significant Accounting Policies [Line Items]
Number of operating segments | Segment			1
Estimated useful life			11 years
Reverse stock split ratio	0.0666	0.0666
Reverse stock split	one-for-fifteen
Capital stock, shares authorized	110,000,000
Common stock, shares authorized	100,000,000		100,000,000	100,000,000
Common stock, par value (in dollars per share) | $ / shares	$ 0.001		$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000		10,000,000	10,000,000
Preferred stock, par value | $ / shares	$ 0.001		$ 0.001	$ 0.001
Essentialis, Inc. [Member]
Schedule Of Significant Accounting Policies [Line Items]
Net intangible assets acquired | $			$ 22.0
Minimum [Member]
Schedule Of Significant Accounting Policies [Line Items]
Estimated useful lives of property and equipment			3 years
Maximum [Member]
Schedule Of Significant Accounting Policies [Line Items]
Estimated useful lives of property and equipment			5 years
Silicon Valley Bank [Member]
Schedule Of Significant Accounting Policies [Line Items]
FDIC insurance limit | $			$ 1.0