X0306 4 2019-04-24 0 0001080014 Innoviva, Inc. INVA 0001483080 Odysseas Kostas D 2000 SIERRA POINT PARKWAY, SUITE 500 BRISBANE CA 94005 1 0 0 0 Common Stock 2019-04-24 4 A 0 16399 0 A 45161 D The Reporting Person was granted restricted stock units ("RSUs"). 100% of the RSUs will vest at the sooner of the next annual stockholder meeting or the one-year anniversary of grant, subject to the Reporting Person's continuous service as an Outside Director through the applicable vesting date. /s/ Odysseas D. Kostas 2019-05-24