The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA HEALTHCARE COMPANY INC | PUT | 00404A109 | 659 | 13,800 | SH | Put | DFND | 0 | 13,800 | 0 | |
| ACTINIUM PHARMACEUTICALS INC | COM | 00507W107 | 915 | 1,590,267 | SH | DFND | 0 | 1,590,267 | 0 | ||
| ADAMIS PHARMACEUTICALS CORP | COM NEW | 00547W208 | 10,115 | 1,935,961 | SH | DFND | 0 | 1,935,961 | 0 | ||
| ADVANCED ACCELERATOR APPLICATIONS SA | SPONSORED ADS | 00790T100 | 3,556 | 52,582 | SH | DFND | 0 | 52,582 | 0 | ||
| AEGLEA BIO THERAPEUTICS INC | COM | 00773J103 | 639 | 129,583 | SH | DFND | 0 | 129,583 | 0 | ||
| AETNA INC | COM | 00817Y108 | 8,034 | 50,523 | SH | DFND | 0 | 50,523 | 0 | ||
| AGIOS PHARMACEUTICALS INC | PUT | 00847X104 | 5,547 | 83,100 | SH | Put | DFND | 0 | 83,100 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 2,376 | 20,225 | SH | DFND | 0 | 20,225 | 0 | ||
| ANTHEM INC | COM | 036752103 | 2,548 | 13,418 | SH | DFND | 0 | 13,418 | 0 | ||
| ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 1,838 | 72,086 | SH | DFND | 0 | 72,086 | 0 | ||
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 960 | 91,413 | SH | DFND | 0 | 91,413 | 0 | ||
| AXOVANT SCIENCES LTD | COM | G0750W104 | 7,698 | 1,118,894 | SH | DFND | 0 | 1,118,894 | 0 | ||
| AXOVANT SCIENCES LTD | PUT | G0750W104 | 25,034 | 3,638,700 | SH | Put | DFND | 0 | 3,638,700 | 0 | |
| BIOGEN INC | COM | 09062X103 | 4,869 | 15,549 | SH | DFND | 0 | 15,549 | 0 | ||
| CATALYST BIOSCIENCES INC | COM NEW | 14888D208 | 2,133 | 421,635 | SH | DFND | 0 | 421,635 | 0 | ||
| CHEMOCENTRYX INC | COM | 16383L106 | 187 | 25,182 | SH | DFND | 0 | 25,182 | 0 | ||
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 605 | 75,000 | SH | DFND | 0 | 75,000 | 0 | ||
| DBV TECHNOLOGIES SA | PUT | 23306J101 | 772 | 18,200 | SH | Put | DFND | 0 | 18,200 | 0 | |
| EAGLE PHARMACEUTICALS INC | COM | 269796108 | 3,807 | 63,835 | SH | DFND | 0 | 63,835 | 0 | ||
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 3,651 | 90,268 | SH | DFND | 0 | 90,268 | 0 | ||
| EVOLENT HEALTH INC | CL A | 30050B101 | 1,399 | 78,600 | SH | DFND | 0 | 78,600 | 0 | ||
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 773 | 139,200 | SH | DFND | 0 | 139,200 | 0 | ||
| GLAXOSMITHKLINE PLC | SPONSORED ADR | 37733W105 | 6,971 | 171,694 | SH | DFND | 0 | 171,694 | 0 | ||
| GLAXOSMITHKLINE PLC | CALL | 37733W105 | 4,060 | 100,000 | SH | Call | DFND | 0 | 100,000 | 0 | |
| GLOBUS MEDICAL INC | CL A | 379577208 | 4,380 | 147,364 | SH | DFND | 0 | 147,364 | 0 | ||
| HALYARD HEALTH INC | COM | 40650V100 | 3,914 | 86,914 | SH | DFND | 0 | 86,914 | 0 | ||
| ICON PLC | SHS | G4705A100 | 2,688 | 23,604 | SH | DFND | 0 | 23,604 | 0 | ||
| INSMED INC | PUT | 457669307 | 8,327 | 266,800 | SH | Put | DFND | 0 | 266,800 | 0 | |
| INTEGER HOLDINGS CORP | COM | 45826H109 | 2,622 | 51,258 | SH | DFND | 0 | 51,258 | 0 | ||
| INTUITIVE SURGICAL INC | PUT | 46120E602 | 2,615 | 2,500 | SH | Put | DFND | 0 | 2,500 | 0 | |
| KONINKLIJKE PHILIPS NV | NY REG SH NEW | 500472303 | 2,795 | 67,829 | SH | DFND | 0 | 67,829 | 0 | ||
| KURA ONCOLOGY INC | COM | 50127T109 | 4,122 | 275,731 | SH | DFND | 0 | 275,731 | 0 | ||
| LUMINEX CORP | COM | 55027E102 | 2,358 | 115,979 | SH | DFND | 0 | 115,979 | 0 | ||
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 1,213 | 26,958 | SH | DFND | 0 | 26,958 | 0 | ||
| MEDTRONIC PLC | SHS | G5960L103 | 4,343 | 55,844 | SH | DFND | 0 | 55,844 | 0 | ||
| OASMIA PHARMACEUTICAL AB | ADR | 67421W109 | 211 | 203,170 | SH | DFND | 0 | 203,170 | 0 | ||
| OTONOMY INC | COM | 68906L105 | 328 | 100,900 | SH | DFND | 0 | 100,900 | 0 | ||
| OTONOMY INC | PUT | 68906L105 | 328 | 100,900 | SH | Put | DFND | 0 | 100,900 | 0 | |
| PFENEX INC | COM | 717071104 | 259 | 85,867 | SH | DFND | 0 | 85,867 | 0 | ||
| PROGENICS PHARMACEUTICALS INC | COM | 743187106 | 652 | 88,523 | SH | DFND | 0 | 88,523 | 0 | ||
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 3,260 | 27,221 | SH | DFND | 0 | 27,221 | 0 | ||
| QUOTIENT LTD | SHS | G73268107 | 11,557 | 2,344,311 | SH | DFND | 0 | 2,344,311 | 0 | ||
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 3,971 | 1,563,307 | SH | DFND | 0 | 1,563,307 | 0 | ||
| SAGE THERAPEUTICS INC | PUT | 78667J108 | 11,862 | 190,400 | SH | Put | DFND | 0 | 190,400 | 0 | |
| SANOFI SA | SPONSORED ADR | 80105N105 | 2,245 | 45,099 | SH | DFND | 0 | 45,099 | 0 | ||
| SEATTLE GENETICS INC | PUT | 812578102 | 5,441 | 100,000 | SH | Put | DFND | 0 | 100,000 | 0 | |
| STEADYMED LTD | SHS | M84920103 | 184 | 54,950 | SH | DFND | 0 | 54,950 | 0 | ||
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 65 | 33,710 | SH | DFND | 0 | 33,710 | 0 | ||
| UNITEDHEALTH GROUP INC | COM | 91324P102 | 2,239 | 11,430 | SH | DFND | 0 | 11,430 | 0 | ||
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 2,261 | 14,874 | SH | DFND | 0 | 14,874 | 0 | ||
| VOCERA COMMUNICATIONS INC | COM | 92857F107 | 1,760 | 56,106 | SH | DFND | 0 | 56,106 | 0 | ||
| XENCOR INC | COM | 98401F105 | 759 | 33,100 | SH | DFND | 0 | 33,100 | 0 | ||
| ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 3,634 | 31,033 | SH | DFND | 0 | 31,033 | 0 | ||
| ZOETIS INC | PUT | 98978V103 | 3,188 | 50,000 | SH | Put | DFND | 0 | 50,000 | 0 | |