<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2010-01-04</periodOfReport>

    <dateOfOriginalSubmission>2010-01-13</dateOfOriginalSubmission>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001089907</issuerCik>
        <issuerName>SWK Holdings Corp</issuerName>
        <issuerTradingSymbol>SWKH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001480555</rptOwnerCik>
            <rptOwnerName>Burgon Paul</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>5314 N. RIVER RUN DRIVE, SUITE 350</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>PROVO</rptOwnerCity>
            <rptOwnerState>UT</rptOwnerState>
            <rptOwnerZipCode>84604</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Interim CFO and Secretary</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3977</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.452</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2006-03-28</value>
            </exerciseDate>
            <expirationDate>
                <value>2012-09-29</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>610149</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote.</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.966</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2006-03-28</value>
            </exerciseDate>
            <expirationDate>
                <value>2012-09-29</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>694216</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote.</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrant</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.966</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2006-04-24</value>
            </exerciseDate>
            <expirationDate>
                <value>2012-10-25</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>127603</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote.</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This amendment to a Form 3 initially filed on January 13, 2010, is to report certain derivative securities of the Issuer held by NightWatch Capital Partners II, L.P., a Delaware limited partnership (&quot;NWCP II&quot;). Mr. Burgon is a Principal of NightWatch Capital Management, LLC, a Delaware limited liability company (&quot;NWCM&quot;), which is the General Partner of NWCP II, and is a Principal and CFO of NightWatch Capital Advisors, LLC (&quot;NWCA&quot;), a Delaware limited liability company, which serves as the managing member of NWCM.  The shares of Common Stock held directly by Mr. Burgon are not being amended.</footnote>
        <footnote id="F2">The Warrants to buy Common Stock (the &quot;Warrants&quot;) are held directly by NWCP II.  NWCM, as the General Partner of NWCP II, has investment discretion over the Warrants held by NWCP II.</footnote>
        <footnote id="F3">Mr. Burgon, as a Principal of NWCM and NWCA, may be deemed to be the beneficial owner of an indeterminate portion of the Warrants held by NWCP II. Mr. Burgon disclaims beneficial ownership of all such Securities except to the extent of any indirect pecuniary interest (within the meaning of Rule 16a-1 of the Exchange Act) therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Paul V. Burgon</signatureName>
        <signatureDate>2010-04-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
