X0306 4 2016-08-16 0 0000906709 NEKTAR THERAPEUTICS NKTR 0001480111 Doberstein Stephen K C/O NEKTAR THERAPEUTICS 455 MISSION BAY BOULEVARD SOUTH SAN FRANCISCO CA 94158 0 1 0 0 SVP & Chief Scientific Officer Common Stock 2016-08-16 4 S 0 1336 17.56 D 18935 D This transaction was executed in multiple trades at prices ranging from $17.47 to $17.67. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer. The total holdings include the remaining portion of the 10,500 shares of restricted stock units ("RSUs") that were previously reported in Table II for the reporting person and which are being reclassified to Table I. These RSUs were granted on December 15, 2015, are convertible on a one-for-one basis into shares of Common Stock of the Company, and vest on a quarterly pro-rata basis over a period of three (3) years from the date of grant. Gil M. Labrucherie, Attorney-in-Fact 2016-08-17