X0202 SCHEDULE 13D/A 0001564590-22-023327 0001846370 XXXXXXXX LIVE 11 Ordinary Shares, nominal value of PS0.05 per share 08/12/2026 false 0001479615 G8128Y157 Silence Therapeutics Plc

72 Hammersmith Road London X0 W14 8TH

Richard Griffiths 44 1534 517500 19-21 Broad Street St Helier Y9 JE2 3RR 0001846370 N Richard Griffiths PF N Y9 14391498.00 0.00 14391498.00 0.00 14391498.00 N 7.97 IN * Consists of (i) 10,777,044 ordinary shares represented by American Depositary Shares ("ADSs") held by Ora Capital Limited; (ii) 600,000 ordinary shares represented by ADSs held by Cream Capital Limited; and (iii) 3,014,454 ordinary shares represented by ADSs held by Mr. Griffiths. Each ADS represents, and at the holder's option is convertible into, three ordinary shares of the Issuer. Mr. Griffiths is a director and the controlling shareholder of both Ora Capital Limited and Cream Capital Limited and possesses the power to direct the voting and disposition of these shares. **This percentage is calculated based upon the 180,628,068 outstanding ordinary shares of the Issuer, as disclosed in the Issuer's last SEC filing. Ordinary Shares, nominal value of PS0.05 per share Silence Therapeutics Plc 72 Hammersmith Road London X0 W14 8TH This Amendment No. 11 to Schedule 13D (this "Amendment"), which amends and supplements the Schedule 13D filed with the Securities and Exchange Commission (the "SEC") on June 15, 2022, as amended on July 20, 2022, October 20, 2022, August 14, 2023, March 27, 2024, December 18, 2024, March 31, 2025, April 24, 2025, May 8, 2025, June 25, 2025 and 6 July 2026 (the "Schedule 13D") on behalf of Richard Ian Griffiths, relates to the ordinary shares, nominal value PS0.05 per share (the "Shares"), of Silence Therapeutics plc (the "Issuer"). This Amendment is being filed to reflect significant dilution as a result of an increase in the share capital of the Issuer together with open market transactions of the Issuer's ADSs by the Reporting Person. Except as amended and supplemented hereby, the Schedule 13D remains in full force and effect. All capitalized terms used in this Amendment but not defined herein shall have the meanings ascribed thereto in the Schedule 13D. Richard Griffiths 19-21 Broad Street, St Helier, Jersey, JE2 3RR n/a n/a Jersey, Channel Islands Mr. Griffiths sold an aggregate of 5,484,320 ADSs in open market transactions between August 10, 2026 and August 12, 2026 for aggregate sales proceeds of $87.7M. n/a Schedule 1 Transactions in ADSs During the Past Sixty Days Richard Griffiths /s/ Richard Ian Griffiths 08/13/2026