SCHEDULE 13G/A 0001425738 XXXXXXXX LIVE 1 Ordinary Shares, nominal value GBP 0.05 per share 03/31/2025 0001479615 Silence Therapeutics plc G8128Y157 72 Hammersmith Road London X0 W14 8TH Rule 13d-1(b) Redmile Group, LLC DE 0.00 6644841.00 0.00 6644841.00 6644841.00 N 4.7 IA OO Redmile Group, LLC's beneficial ownership of the Issuer's Ordinary Shares ("Ordinary Shares") is comprised of 2,214,947 American Depositary Shares ("ADSs"), each of which represents three Ordinary Shares, that are owned by certain private investment vehicles managed by Redmile Group, LLC. The reported securities may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Percentage based on 141,674,074 Ordinary Shares outstanding as of January 31, 2025, as reported by the Issuer in its Form 10-K for the fiscal year ended December 31, 2024 filed with the Securities and Exchange Commission on February 27, 2025 (the "Form 10-K"). Jeremy C. Green X0 0.00 6644841.00 0.00 6644841.00 6644841.00 N 4.7 HC IN Jeremy C. Green's beneficial ownership of Ordinary Shares is comprised of 2,214,947 ADSs, each of which represents three Ordinary Shares, that are owned by certain private investment vehicles managed by Redmile Group, LLC. The reported securities may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Percentage based on 141,674,074 Ordinary Shares outstanding as of January 31, 2025, as reported by the Issuer in the Form 10-K. Silence Therapeutics plc 72 Hammersmith Road, London, United Kingdom, W14 8TH Redmile Group, LLC Jeremy C. Green Redmile Group, LLC One Letterman Drive Building D, Suite D3-300 The Presidio of San Francisco San Francisco, California 94129 Jeremy C. Green c/o Redmile Group, LLC (NY Office) 45 W. 27th Street, Floor 11 New York, NY 10001 Redmile Group, LLC: Delaware Jeremy C. Green: United Kingdom N IA HC Redmile Group, LLC - 6,644,841 (1) Jeremy C. Green - 6,644,841 (1) Redmile Group, LLC - 4.7% (2) Jeremy C. Green - 4.7% (2) Redmile Group, LLC - 0 Jeremy C. Green - 0 Redmile Group, LLC - 6,644,841 (1) Jeremy C. Green - 6,644,841 (1) Redmile Group, LLC - 0 Jeremy C. Green - 0 Redmile Group, LLC - 6,644,841 (1) Jeremy C. Green - 6,644,841 (1) (1) Redmile Group, LLC's and Jeremy C. Green's beneficial ownership of the Issuer's Ordinary Shares is comprised of 2,214,947 ADSs, each of which represents three Ordinary Shares, that are owned by certain private investment vehicles managed by Redmile Group, LLC. The reported securities may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. (2) Percentage based on 141,674,074 Ordinary Shares outstanding as of January 31, 2025, as reported by the Issuer in the Form 10-K. N Y Y N See the response to Item 4. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Redmile Group, LLC /s/ Jeremy C. Green 05/15/2025 Jeremy C. Green /s/ Jeremy C. Green 05/15/2025