X0306 4 2020-10-26 0 0001479419 Kala Pharmaceuticals, Inc. KALA 0001298079 Brazzell Romulus K C/O KALA PHARMACEUTICALS, INC. 490 ARSENAL WAY, SUITE 120 WATERTOWN MA 02472 0 1 0 0 Chief Medical Officer Common Stock 2020-10-26 4 A 0 81000 0 A 276496 D On June 25, 2020, the reporting person was granted performance-based restricted stock unit ("RSUs") under the Issuer's 2017 Equity Incentive Plan. Each RSU represents a contingent right to receive one share of the Issuer's common stock. Subject to the reporting person's continued employment with the Issuer, the RSUs will vest as to 50% of the shares underlying the RSUs on October 26, 2021, the first anniversary of the achievement of the performance condition, and as to the remaining 50% of the shares underlying the RSUs on October 26, 2022, the second anniversary of the achievement of the performance condition. Includes 100,000 unvested RSUs. /s/ Eric Trachtenberg, Attorney-in-Fact 2020-10-28