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        <entityName>Revance Therapeutics, Inc.</entityName>
        <issuerAddress>
            <street1>7555 GATEWAY BLVD.</street1>
            <city>NEWARK</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>94560</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>510-742-3400</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Essentia Biosystems, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
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        <entityType>Corporation</entityType>
        <yearOfInc>
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    </primaryIssuer>

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            <relatedPersonName>
                <firstName>L.</firstName>
                <middleName>Daniel</middleName>
                <lastName>Browne</lastName>
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                <street1>7555 Gateway Boulevard</street1>
                <city>Newark</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94560</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ron</firstName>
                <lastName>Eastman</lastName>
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                <city>Newark</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94560</zipCode>
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                <firstName>Vicente</firstName>
                <lastName>Trelles</lastName>
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                <stateOrCountry>CA</stateOrCountry>
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                <zipCode>94560</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Byrnes</lastName>
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            <relatedPersonAddress>
                <street1>7555 Gateway Boulevard</street1>
                <city>Newark</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94560</zipCode>
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            <relatedPersonRelationshipList>
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                <firstName>Phyllis</firstName>
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                <zipCode>94560</zipCode>
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                <lastName>Glasheen</lastName>
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        <relatedPersonInfo>
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                <lastName>Tunnicliffe</lastName>
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                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94560</zipCode>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001479290-11-000001</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2011-01-24</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
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        <businessCombinationTransaction>
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            <clarificationOfResponse>Issuance of Secured Subordinated Convertible Promissory Notes and Warrants to purchase Common Stock and the underlying Preferred and Common Stock issuable upon exercise and conversion thereof</clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
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            <totalAmountSold>50919191</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>33</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
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                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
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                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Revance Therapeutics, Inc.</issuerName>
                <signatureName>/s/ Craig Dauchy</signatureName>
                <nameOfSigner>Craig Dauchy</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2012-09-14</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
