X0306 4 2020-03-31 0 0001755237 Cyclerion Therapeutics, Inc. CYCN 0001478485 Hecht Peter M C/O CYCLERION THERAPEUTICS, INC. 301 BINNEY STREET CAMBRIDGE MA 02142 1 1 0 0 Chief Executive Officer Common Stock 223736 D Common Stock 485 I The 2000 Trust for Alexis Mae Hecht Common Stock 485 I The 2000 Trust for Malcolm Peter Hecht Common Stock 485 I The 2000 Trust for Zoe Niovi Hecht Employee Stock Option (Right to Buy) 2.65 2020-03-31 4 A 0 153846 2.65 A 2030-03-31 Common Stock 153846 153846 D Due to administrative error, the Reporting Person's last filed Form 4 under-reported the shares beneficially owned by 2,000 shares. This Form 4 reflects the corrected total beneficial ownership for this Reporting Person. These shares are held in the referenced trust for the benefit of the reporting person's child. The reporting person's spouse is the trustee of this trust. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or any other purpose. The Compensation Committee approved the stock option award to the reporting person in order to offset his low-to-market total cash compensation and provide him with a market-aligned total compensation package for 2019, 2020, and 2021. 36,436 options under the award are intended to offset his below-market total cash salary for 2019, and 58,705 options under the award are intended to offset his below-market total cash compensation for each of 2020 and 2021. The options, granted as an annual performance award, vests in seventy-two equal monthly installments over a six year period on each monthly anniversary of January 1, 2020 until fully vested. /s/ Anjeza Gjino, Attorney-in-Fact 2020-04-02