<?xml version="1.0" encoding="UTF-8"?><ns2:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:ns2="http://www.sec.gov/edgar/ownership">
    <ns2:headerData>
        <ns2:submissionType>144</ns2:submissionType>
        <ns2:filerInfo>
            <ns2:filer>
                <ns2:filerCredentials>
                    <ns2:cik>0001780649</ns2:cik>
                    <ns2:ccc>XXXXXXXX</ns2:ccc>
                </ns2:filerCredentials>
            </ns2:filer>
            <ns2:liveTestFlag>LIVE</ns2:liveTestFlag>



        </ns2:filerInfo>
    </ns2:headerData>
    <ns2:formData>
        <ns2:issuerInfo>
            <ns2:issuerCik>0001478320</ns2:issuerCik>
            <ns2:issuerName>Adaptive Biotechnologies Corporation</ns2:issuerName>
            <ns2:secFileNumber>001-38957</ns2:secFileNumber>
            <ns2:issuerAddress>
                <com:street1>1165 Eastlake Avenue East</com:street1>
                <com:city>Seattle</com:city>
                <com:stateOrCountry>WA</com:stateOrCountry>
                <com:zipCode>98109</com:zipCode>
            </ns2:issuerAddress>
            <ns2:issuerContactPhone>1-206-659-0067</ns2:issuerContactPhone>
            <ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Chad Robins</ns2:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <ns2:relationshipsToIssuer>
                <ns2:relationshipToIssuer>Officer</ns2:relationshipToIssuer>
            </ns2:relationshipsToIssuer>
        </ns2:issuerInfo>
        <ns2:securitiesInformation>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:brokerOrMarketmakerDetails>
                <ns2:name>Goldman Sachs &amp; Co. LLC</ns2:name>
                <ns2:address>
                    <com:street1>200 West Street</com:street1>
                    <com:city>New York</com:city>
                    <com:stateOrCountry>NY</com:stateOrCountry>
                    <com:zipCode>10282</com:zipCode>
                </ns2:address>
            </ns2:brokerOrMarketmakerDetails>
            <ns2:noOfUnitsSold>37263</ns2:noOfUnitsSold>
            <ns2:aggregateMarketValue>552982.92</ns2:aggregateMarketValue>
            <ns2:noOfUnitsOutstanding>153981561</ns2:noOfUnitsOutstanding>
            <ns2:approxSaleDate>04/08/2026</ns2:approxSaleDate>
            <ns2:securitiesExchangeName>NASD</ns2:securitiesExchangeName>
        </ns2:securitiesInformation>
        <ns2:securitiesToBeSold>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:acquiredDate>09/01/2009</ns2:acquiredDate>
            <ns2:natureOfAcquisitionTransaction>Founder's Shares</ns2:natureOfAcquisitionTransaction>
            <ns2:nameOfPersonfromWhomAcquired>The Issuer</ns2:nameOfPersonfromWhomAcquired>
            <ns2:isGiftTransaction>N</ns2:isGiftTransaction>
            <ns2:amountOfSecuritiesAcquired>37263</ns2:amountOfSecuritiesAcquired>
            <ns2:paymentDate>09/01/2009</ns2:paymentDate>
            <ns2:natureOfPayment>None</ns2:natureOfPayment>
        </ns2:securitiesToBeSold>
        <ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</ns2:nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>03/02/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>41666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>653647.87</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>04/06/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>41666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>603273.68</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>02/02/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>41666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>762950.29</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>03/02/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>41666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>660993.59</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>02/02/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>41666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>774225.11</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>02/02/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>41666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>767821.05</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>02/27/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>99225</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>1589941.71</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>03/02/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>41666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>655964.5</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>02/27/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>83666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>1334138.04</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>04/06/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>41666</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>597515.44</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>03/02/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>96323</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>1546542.82</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>03/02/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>67703</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>1056383.45</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>03/03/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>4452</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>71681.21</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:securitiesSoldInPast3Months>
            <ns2:sellerDetails>
                <ns2:name>Chad M. Robins</ns2:name>
                <ns2:address>
                    <com:street1>1165 Eastlake Avenue East</com:street1>
                    <com:city>Seattle</com:city>
                    <com:stateOrCountry>WA</com:stateOrCountry>
                    <com:zipCode>98109</com:zipCode>
                </ns2:address>
            </ns2:sellerDetails>
            <ns2:securitiesClassTitle>Common Stock</ns2:securitiesClassTitle>
            <ns2:saleDate>03/03/2026</ns2:saleDate>
            <ns2:amountOfSecuritiesSold>48631</ns2:amountOfSecuritiesSold>
            <ns2:grossProceeds>752258.35</ns2:grossProceeds>
        </ns2:securitiesSoldInPast3Months>
        <ns2:remarks>The sales of shares set forth herein are made in connection with a selling plan dated 8/11/2025, that is intended to comply with Rule 10b5-1(c).</ns2:remarks>
        <ns2:noticeSignature>
            <ns2:noticeDate>04/08/2026</ns2:noticeDate>
            <ns2:planAdoptionDates>
                <ns2:planAdoptionDate>08/11/2025</ns2:planAdoptionDate>
            </ns2:planAdoptionDates>
            <ns2:signature>Goldman Sachs &amp; Co. LLC on behalf of Chad Robins</ns2:signature>
        </ns2:noticeSignature>
    </ns2:formData>
</ns2:edgarSubmission>
