144 0001780660 XXXXXXXX LIVE 0001478320 ADAPTIVE BIOTECHNOLOGIES CORPORATION 001-38957 1165 Eastlake Avenue East Seattle WA 98109 2066590067 FRANCIS LO Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

136706 2110740.64 152665188 12/15/2025 NASDAQ Common 12/15/2025 Exercise of Stock Options Issuer N 100147 12/15/2025 Cash Common 03/04/2023 Restricted Stock Units Issuer N 36559 03/04/2023 N/A Y The securities to be sold were acquired upon the vesting of restricted stock units during the period of 03/04/2023 through 03/04/2025. The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 12/15/2025 09/15/2025 /s/ Francis Lo