Income Taxes (Tables)

12 Months Ended

Dec. 31, 2023

Income Tax Disclosure [Abstract]

Schedule of Components of Loss Before Provision for Income Taxes

The components of loss before provision for income taxes for the periods presented were as follows (in thousands):

	Year Ended December 31,
	2023			2022			2021
Domestic	$	(225,335	)	$	(200,427	)	$	(207,314	)
Foreign		31			59			16
Total loss before provision for income taxes	$	(225,304	)	$	(200,368	)	$	(207,298	)

Schedule of Components of Deferred Tax Assets and Liabilities

The significant components of our deferred tax assets and liabilities as of the dates presented were as follows (in thousands):

	December 31,
	2023			2022
Deferred tax assets
Net operating losses	$	251,724		$	210,609
Tax credit carryforward		43,528			36,848
Nonqualifying stock options		29,166			23,885
Operating lease liabilities		25,357			27,199
Deferred revenue		18,874			26,170
Capitalized research and development		42,134			40,957
Other		6,146			5,859
Total deferred tax assets		416,929			371,527
Less: Valuation allowance		(402,424	)		(346,578	)
Deferred tax assets, net of valuation allowance		14,505			24,949
Deferred tax liabilities
Tangible and intangible assets		(1,281	)		(4,897	)
Right-of-use assets		(13,224	)		(20,052	)
Net deferred taxes	$	—		$	—

Schedule of Reconciliation of Effective Tax Rate of Provision for Income Taxes Differs from Federal Statutory Rate

The effective tax rate of our provision for income taxes differs from the federal statutory rate for the periods presented as follows:

	Year Ended December 31,
	2023	2022	2021
Statutory rate	21.0%	21.0%	21.0%
State tax, net of federal tax benefit	4.0	3.8	8.3
Share-based compensation	(2.9)	(2.0)	14.1
Permanent items	(0.1)	(0.2)	(0.1)
Credits	2.3	3.0	4.7
Other	1.0	(1.2)	(0.3)
Change in valuation allowance	(25.3)	(24.4)	(47.7)
Total	0.0%	0.0%	0.0%

Schedule of Change in Unrecognized Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized tax benefits for the dates presented are as follows (in thousands):

Balance at December 31, 2020	$	3,489
Additions in 2021		3,426
Balance at December 31, 2021		6,915
Additions in 2022		1,202
Balance at December 31, 2022		8,117
Additions in 2023		1,186
Balance at December 31, 2023	$	9,303