Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Operating activities
Net loss	$ (155,837)	$ (160,199)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation expense	15,569	14,364
Noncash lease expense	5,491	5,423
Share-based compensation expense	47,352	41,183
Intangible assets amortization	1,270	1,270
Investment amortization	(6,225)	1,825
Inventory reserve	931	2,638
Noncash interest expense	4,563	653
Other	165	(20)
Changes in operating assets and liabilities
Accounts receivable, net	8,798	(9,139)
Inventory	(6,815)	(2,212)
Prepaid expenses and other current assets	(3,964)	601
Accounts payable and accrued liabilities	(10,746)	(3,419)
Operating lease right-of-use assets and liabilities	(6,688)	(3,041)
Deferred revenue	(23,180)	(44,018)
Other	(76)	165
Net cash used in operating activities	(129,392)	(153,926)
Investing activities
Purchases of property and equipment	(9,399)	(13,807)
Purchases of marketable securities	(307,563)	(113,744)
Proceeds from maturities of marketable securities	443,402	228,000
Net cash provided by investing activities	126,440	100,449
Financing activities
Proceeds from exercise of stock options	2,158	7,568
Proceeds from revenue interest purchase agreement, net of issuance costs		124,691
Net cash provided by financing activities	2,158	132,259
Net (decrease) increase in cash, cash equivalents and restricted cash	(794)	78,782
Cash, cash equivalents and restricted cash at beginning of year	92,428	141,203
Cash, cash equivalents and restricted cash at end of period	91,634	219,985
Noncash investing and financing activities
Purchases of equipment included in accounts payable and accrued liabilities	1,308	2,619
Revenue interest purchase agreement issuance costs included in accounts payable and accrued liabilities		$ 316
Supplemental disclosure of cash flow information
Cash paid for interest	$ 7,089