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Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2025
Stock-Based Compensation  
Schedule of stock-based compensation expense

Stock-based compensation expense reflected in the statement of operations was as follows:

Year Ended

December 31, 

  ​ ​ ​

2025

  ​ ​ ​

2024

General and administrative

$

969,990

$

2,510,444

Research and development

 

827,686

1,326,326

$

1,797,676

$

3,836,770

Schedule of stock option activity

The following table summarizes stock option activity:

  ​ ​ ​

  ​ ​ ​

  ​ ​ ​

Weighted

  ​ ​ ​

Average

Remaining

Aggregate

Weighted

Contractual

Intrinsic

Number of

Average

Life

Value

Options

Exercise Price

(Years)

(Thousands)

Options outstanding at December 31, 2024

 

2,336,020

$

11.39

7.3

$

1,298

Options granted

220,000

$

2.09

302

Options exercised

(14,284)

$

0.14

47

Options canceled

(147,233)

$

8.37

37

Options outstanding at December 31, 2025

 

2,394,503

$

10.79

6.9

 

$

777

Options exercisable at December 31, 2025

2,059,481

$

11.88

6.6

 

$

528

Schedule of weighted average assumptions used to determine fair value of options

The assumptions utilized in the fair value calculations for stock options granted during the years ended December 31, 2025 and 2024, respectively, were as follows:

  ​ ​ ​

Year Ended

 

  ​ ​ ​

Year Ended

 

December 31, 2025

 

December 31, 2024

 

Risk-free interest rate

 

3.83

%

 

4.18

%

Expected life

 

5.6

 

5.3

Expected volatility

 

116

%

 

123

%

Expected dividend yield